Figure 6From: Arsenic trioxide induces oxidative stress, DNA damage, and mitochondrial pathway of apoptosis in human leukemia (HL-60) cellsATO-induced intrinsic pathway of apoptosis in HL-60 cells. ATO induces oxidative stress in APL cells through lipid peroxidation, GSH content changed and DNA damage. It changes mitochondrial membrane potential and modulates expression and translocation of apoptotic proteins, which lead to caspase3 activity and apoptosis in HL-60 cells.Back to article page