Effects of ATP on the growth and migration of nasopharyngeal carcinoma cell lines. A: Dose-dependent and time-dependent effects of ATP on 5-8 F and CNE-2 cell growth after incubation with ATP. The data represent the means ± SD of 3 independent experiments performed in quadruplicate. Statistical significance between the control and treated conditions: P < 0.05 for 50–100 μM of 24 h and 20 μM of 48 h and 72 h; P < 0.01 for other time points. B: ATP inhibited the migration of 5-8 F and CNE-2 cells. NPC cell migration was evaluated after incubation with ATP (10 μM) for 24 h. The data represent means ± SD of relative migration vs. control from 3 experiments. Statistical significance between the control and treated conditions: *P < 0.05.