The expression profile of Dopamine D2 receptor, MGMT and VEGF in different histological subtypes of pituitary adenomas: a study of 197 cases and indications for the medical therapy

Table 2 Association of D2R, MGMT and VEGF expression with clinicopathological characteristics from patients with PA

Parameters	No. of patients	D2R		P	MGMT		P	VEGF		P
Parameters	No. of patients	Low	High	P	Low	High	P	Low	High	P
Cases	197	69	128		170	27		81	116
Gender				0.736			0.826			0.646
Male	106	36	70		92	14		42	64
Female	91	33	58		78	13		39	52
Aggressive				0.410			0.220			0.602
Yes	64	25	39		58	6		28	36
No	133	44	89		112	21		53	80
Recurrence				0.741			0.096			0.199
Yes	16	5	11		16	0		9	7
No	181	64	117		154	27		72	109
Tumor size				0.829			0.884			0.823
≤10 mm	16	6	10		14	2		7	9
>10 mm	181	63	118		156	25		74	107
Tumor texture				0.309			0.913			0.090
Tender	159	53	106		137	22		70	89
Tenacious	38	16	22		33	5		11	27
Bromocriptine				0.096			0.919			0.344
Yes	8	5	3		7	1		2	6
No	189	64	125		163	26		79	110

ISSN: 1756-9966