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Table 2 Association of D2R, MGMT and VEGF expression with clinicopathological characteristics from patients with PA

From: The expression profile of Dopamine D2 receptor, MGMT and VEGF in different histological subtypes of pituitary adenomas: a study of 197 cases and indications for the medical therapy

Parameters No. of patients D2R P MGMT P VEGF P
Low High Low High Low High
Cases 197 69 128   170 27   81 116  
Gender     0.736    0.826    0.646
Male 106 36 70 92 14 42 64
Female 91 33 58 78 13 39 52
Aggressive     0.410    0.220    0.602
Yes 64 25 39 58 6 28 36
No 133 44 89 112 21 53 80
Recurrence     0.741    0.096    0.199
Yes 16 5 11 16 0 9 7
No 181 64 117 154 27 72 109
Tumor size     0.829    0.884    0.823
≤10 mm 16 6 10 14 2 7 9
>10 mm 181 63 118 156 25 74 107
Tumor texture     0.309    0.913    0.090
Tender 159 53 106 137 22 70 89
Tenacious 38 16 22 33 5 11 27
Bromocriptine     0.096    0.919    0.344
Yes 8 5 3 7 1 2 6
No 189 64 125 163 26 79 110
  1. Low, low expression (score of ≤3); High, high expression (score of >3).