Table 1 Stated are IC 50 values after 72 h of HDAC8 inhibitor treatment in eight urothelial cancer cell lines and a representative normal uroepithelial control
From: Histone deacetylase 8 is deregulated in urothelial cancer but not a target for efficient treatment
IC50[μM] | Compound 2 | Compound 5 | Compound 6 | |
|---|---|---|---|---|
VM-CUB1 | ≥ 50 | 18.7 | 16 | |
SW-1710 | ≥ 50 | 20.8 | 18.8 | |
RT-112 | ≥ 50 | 9.7 | 9.1 | |
639-V | ≥ 50 | 12.6 | 18.6 | |
UM-UC-3 | ≥ 50 | 18.9 | 18.2 | |
Normal Uroepithelial Control | ≥ 50 | 24.2 | 10.2 |