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Table 1 Stated are IC 50 values after 72 h of HDAC8 inhibitor treatment in eight urothelial cancer cell lines and a representative normal uroepithelial control

From: Histone deacetylase 8 is deregulated in urothelial cancer but not a target for efficient treatment

  IC50[μM] Compound 2 Compound 5 Compound 6
VM-CUB1   ≥ 50 18.7 16
SW-1710   ≥ 50 20.8 18.8
RT-112   ≥ 50 9.7 9.1
639-V   ≥ 50 12.6 18.6
UM-UC-3   ≥ 50 18.9 18.2
Normal Uroepithelial Control   ≥ 50 24.2 10.2