Table 3 Changes of prothrombotic markers in patients with prostate cancer who underwent surgery with total intravenous anesthesia with target-controlled infusion (TIVA-TCI) before the induction of anaesthesia (T0), 1 hr post-surgery (T1) and 24 hrs post-surgery (T2)
| Â | T0 | T1 | T2 | P | ||
|---|---|---|---|---|---|---|
| Â | Â | Â | Â | T0 vs T1 | T1 vs T2 | T0 vs T2 |
Screen clotting time | Â | Â | Â | Â | Â | Â |
- PT (%) | 93.1 (1.3) | 85.6 (1.2) | 82.5 (1.2) | 0.001 | 0.21 | 0.001 |
- PTT (sec) | 29.6 (0.6) | 26.8 (0.7) | 27.6 (0.8) | 0.003 | 0.07 | 0.18 |
Procoagulant markers | Â | Â | Â | Â | Â | Â |
- Fibrinogen (mg/dL) | 285.5 (7.1) | 262.3 (6.6) | 353.3 (8.8) | 0.004 | 0.001 | 0.001 |
- TAT (ng/L) | 9.1 (1.9) | 22.8 (3.2) | 9.7 (2.4) | 0.002 | 0.004 | 0.79 |
- F1 + 2 (pmol/L) | 210.8 (27.3) | 622.1 (64.2) | 364.4 (45.6) | 0.001 | 0.001 | 0.007 |
- FVIII (%) | 142.9 (8.1) | 194.2 (9.3) | 162.3 (5.6) | 0.001 | 0.004 | 0.04 |
Fibrinolysis markers | Â | Â | Â | Â | Â | Â |
- PAI-1 (ng/ml) | 15.2 (1.4) | 21.9 (5.8) | 36.1 (9.8) | 0.41 | 0.20 | 0.04 |
- D-dimer (μg/L) | 127.1 (12.8) | 721.4 (170.4) | 364.2 (28.3) | 0.001 | 0.02 | 0.001 |
Haemostatic system inhibitors | Â | Â | Â | Â | Â | Â |
- AT (%) | 102.1 (1.8) | 90.6 (1.9) | 87.4 (2.4) | 0.001 | 0.38 | 0.001 |
- protein C (%) | 109.6 (2.8) | 95.4 (2.8) | 87.8 (2.8) | 0.004 | 0.03 | 0.001 |
- protein S (%) | 93.8 (3.1) | 84.2 (2.8) | 82.4 (2.4) | 0.01 | 0.56 | 0.001 |
Platelet-aggregating properties | Â | Â | Â | Â | Â | Â |
- p-selectin (ng/ml) | 37.9 (2.0) | 36.8 (2.4) | 33.5 (2.6) | 0.78 | 0.37 | 0.28 |