Figure 1From: Mutations of human DNA topoisomerase I at poly(ADP-ribose) binding sites: modulation of camptothecin activity by ADP-ribose polymersThree-dimensional representation of the hTop1 protein-DNA binary complex. The lateral chains of the residues forming the three putative PAR binding sites have been mapped on the hTop1 structure. The positively charged residues are shown in red and the hydrophobic ones in green.Back to article page