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Table 1 Effect of PPI treatment on expression of resistance-relevant miRNAs

From: Proton pump inhibitors (PPIs) impact on tumour cell survival, metastatic potential and chemotherapy resistance, and affect expression of resistance-relevant miRNAs in esophageal cancer

miRNAs

SCC

EAC

miR-16

−1,26 ± 0,12

/

miR-23a

/

+1,51 ± 0,20

miR-24

/

+1,47 ± 0,17

miR-26a

/

+1,97 ± 0,3

miR-106

−1,43 ± 0,14

/

miR-141

+1,19 ± 0,07

+1,49 ± 0,16

miR-155

−1,45 ± 0,09

/

miR-200a

/

+1,35 ± 0,05

miR-200b

+1,18 ± 0,08

+1,25 ± 0,11

miR-200c

/

+1,59 ± 0,09

miR-221

−1,58 ± 0,17

/

miR-222

−1,31 ± 0,26

/

miR-296-5p

/

−1,31 ± 0,29

miR-376a

±1,34 ± 0,16

−1,55 ± 0,08

  1. The table presents an overview of the significant deregulation/fold-change in expression of selected miRNAs in SCC and EAC cells after treatment with esomeprazole (LD50) compared to controls. +: significant upregulation. -: significant downregulation.