Figure 7
Proposed model of the mechanisms involved in PAF-mediated EGFR transactivation in SKOV-3 ovarian cancer cells. In response to PAF, activated PAFR triggers the EGFR/ERK transactivation pathway via PLCĪ², intracellular Ca2+, Src and the ADAM-mediated release of EGFR ligand HB-EGF. PAF also triggers the PKC pathway to couple to ERK phosphorylation.