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Table 2 Association of expression level of SIRT1, N1IC, and snail with clinicopathological variables

From: Correlation and prognostic value of SIRT1 and Notch1 signaling in breast cancer

  

SIRT1

N1IC

Snail

Characteristics

N

High

Low N (%)

χ 2

p- value

High N (%)

Low N (%)

χ 2

p -value

High N (%)

Low N (%)

χ 2

p -value

Age (years)

             

  < 50

74

57 (77.0)

17 (23)

0.008

0.930

60 (81.1)

14 (18.9)

3.177

0.075

49 (66.2)

25 (33.8)

1.102

0.294

  ≥ 50

76

59 (77.6)

17 (22.4)

52 (68.4)

24 (31.6)

44 (57.9)

32 (42.1)

Lymph node metastasis

             

  Absence

83

70 (84.3)

13 (15.7)

5.2

0.023*

53 (63.9)

30 (36.1)

11.48

0.001*

45 (54.2)

38 (45.8)

4.778

0.029*

  Presence

67

46 (68.7)

21 (31.3)

59 (88.0)

8 (12.0)

48 (71.6)

19 (28.4)

TNM stage

             

  I–III

128

98 (76.6)

30 (23.4)

0.3

0.788

94 (73.4)

34 (26.6)

1.457

0.227

76 (59.4)

52 (40.6)

2.552

0.110

  IV

22

18 (81.8)

4 (18.2)

18 (81.8)

4 (18.2)

17 (77.3)

5 (22.7)

Histological grade

             

  1 + 2

102

81 (79.4)

21 (20.6)

0.79

0.375

73 (71.6)

29 (28.4)

1.617

0.203

60 (58.8)

42 (41.2)

1.365

0.243

  3

48

35 (72.9)

13 (27.1)

39 (81.3)

9 (18.7)

33 (68.8)

15 (31.2)

ER status

             

  Negative

71

53 (74.6)

18 (25.4)

0.56

0.456

51 (71.8)

20 (28.2)

0.573

0.449

44 (62.0)

27 (38.0)

0

0.995

  Positive

79

63 (79.7)

16 (20.3)

61 (77.2)

18 (22.8)

49 (62.0)

30 (38.0)

PR status

             

  Negative

71

49 (69.0)

22 (31.0)

5.32

0.021*

52 (73.2)

19 (26.8)

0.145

0.703

41 (57.7)

30 (42.3)

1.035

0.309

  Positive

79

67 (84.8)

12 (15.2)

60 (75.9)

19 (24.1)

52 (65.8)

27 (34.2)

HER2 status

             

  Negative

111

23 (20.7)

88 (79.3)

0.92

0.337

32 (28.8)

79 (71.2)

2.758

0.097

44 (39.6)

67 (60.4)

0.487

0.485

  Positive

39

11 (28.2)

28 (71.8)

6 (15.4)

33 (84.6)

13 (33.3)

26 (66.7)

Adjuvant therapy

             

  Chemo

75

57 (76.0)

18 (24.0)

0.268

0.966

57 (76.0)

18 (24.0)

1.313

0.726

47 (63.1)

28 (36.9)

5.853

0.119

  Chemo + Radio

15

12 (80.0)

3 (20.0)

13 (86.7)

2 (13.3)

13 (86.7)

2 (13.3)

  Chemo + Radio + Endo

12

9 (75.0)

3 (25.0)

9 (75.0)

3 (25.0)

9 (75.0)

3 (25.0)

  Unknown

48

38 (79.2)

10 (20.8)

35 (72.9)

13 (27.1)

27 (56.3)

21 (43.7)

  1. Chemo: chemotherapy; Radio: radiotherapy; Endo: endocrine therapy; N: number of patients; *P < 0.05.
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Journal of Experimental & Clinical Cancer Research

ISSN: 1756-9966

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