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Table 2 Association of expression level of SIRT1, N1IC, and snail with clinicopathological variables

From: Correlation and prognostic value of SIRT1 and Notch1 signaling in breast cancer

   SIRT1 N1IC Snail
Characteristics N High Low N (%) χ 2 p- value High N (%) Low N (%) χ 2 p -value High N (%) Low N (%) χ 2 p -value
Age (years)              
  < 50 74 57 (77.0) 17 (23) 0.008 0.930 60 (81.1) 14 (18.9) 3.177 0.075 49 (66.2) 25 (33.8) 1.102 0.294
  ≥ 50 76 59 (77.6) 17 (22.4) 52 (68.4) 24 (31.6) 44 (57.9) 32 (42.1)
Lymph node metastasis              
  Absence 83 70 (84.3) 13 (15.7) 5.2 0.023* 53 (63.9) 30 (36.1) 11.48 0.001* 45 (54.2) 38 (45.8) 4.778 0.029*
  Presence 67 46 (68.7) 21 (31.3) 59 (88.0) 8 (12.0) 48 (71.6) 19 (28.4)
TNM stage              
  I–III 128 98 (76.6) 30 (23.4) 0.3 0.788 94 (73.4) 34 (26.6) 1.457 0.227 76 (59.4) 52 (40.6) 2.552 0.110
  IV 22 18 (81.8) 4 (18.2) 18 (81.8) 4 (18.2) 17 (77.3) 5 (22.7)
Histological grade              
  1 + 2 102 81 (79.4) 21 (20.6) 0.79 0.375 73 (71.6) 29 (28.4) 1.617 0.203 60 (58.8) 42 (41.2) 1.365 0.243
  3 48 35 (72.9) 13 (27.1) 39 (81.3) 9 (18.7) 33 (68.8) 15 (31.2)
ER status              
  Negative 71 53 (74.6) 18 (25.4) 0.56 0.456 51 (71.8) 20 (28.2) 0.573 0.449 44 (62.0) 27 (38.0) 0 0.995
  Positive 79 63 (79.7) 16 (20.3) 61 (77.2) 18 (22.8) 49 (62.0) 30 (38.0)
PR status              
  Negative 71 49 (69.0) 22 (31.0) 5.32 0.021* 52 (73.2) 19 (26.8) 0.145 0.703 41 (57.7) 30 (42.3) 1.035 0.309
  Positive 79 67 (84.8) 12 (15.2) 60 (75.9) 19 (24.1) 52 (65.8) 27 (34.2)
HER2 status              
  Negative 111 23 (20.7) 88 (79.3) 0.92 0.337 32 (28.8) 79 (71.2) 2.758 0.097 44 (39.6) 67 (60.4) 0.487 0.485
  Positive 39 11 (28.2) 28 (71.8) 6 (15.4) 33 (84.6) 13 (33.3) 26 (66.7)
Adjuvant therapy              
  Chemo 75 57 (76.0) 18 (24.0) 0.268 0.966 57 (76.0) 18 (24.0) 1.313 0.726 47 (63.1) 28 (36.9) 5.853 0.119
  Chemo + Radio 15 12 (80.0) 3 (20.0) 13 (86.7) 2 (13.3) 13 (86.7) 2 (13.3)
  Chemo + Radio + Endo 12 9 (75.0) 3 (25.0) 9 (75.0) 3 (25.0) 9 (75.0) 3 (25.0)
  Unknown 48 38 (79.2) 10 (20.8) 35 (72.9) 13 (27.1) 27 (56.3) 21 (43.7)
  1. Chemo: chemotherapy; Radio: radiotherapy; Endo: endocrine therapy; N: number of patients; *P < 0.05.