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Table 1 KRAS status analyzed in tumor tissue and plasma samples by direct sequencing and PNA-PCR assays

From: KRAS mutations in tumor tissue and plasma by different assays predict survival of patients with metastatic colorectal cancer

   Tumor tissue Plasma Total
Assay KRASstatus (n = 416) (n = 242) (n = 658)
  Wild type 260 (63) 201 (83) 461 (70)
  Mutated 156 (38) 41 (17) 197* (30)
  Codon 12 118 (28) 30 (12) 148 (22)
Direct sequencing 12 D 50 13 63
  12 V 39 10 49
  Other 29 7 36
  Codon 13 38 (9) 11 (5) 49 (8)
  Wild type 221 (53) 166 (69) 387 (59)
  Mutated 195 (47) 76 (31) 271* (41)
  Codon 12 133 (32) 56 (23) 189 (29)
PNA-PCR 12 D 57 26 83
  12 V 46 17 63
  Other 30 13 43
  Codon 13 62 (15) 20 (8) 82 (12)
  1. Data expressed as n (%).
  2. *p < 0.001.PNA-PCR, peptide-nucleic-acid-mediated polymerase chain reaction clamping.