Skip to main content

Table 2 Comparison of KRAS status in tumor tissue and pre-surgery plasma in 242 patients with available paired samples*

From: KRAS mutations in tumor tissue and plasma by different assays predict survival of patients with metastatic colorectal cancer

 

Tumor tissue

Plasma

Direct sequencing

 

Wild type

Mutated

Total

Kappa

p value †

Direct sequencing

     

Wild-type (%)

138 (57)

63 (26)

201

·278

<0 · 001

Mutated (%)

11 (5)

30 (12)

41

  

Total

149

93

242

  

PNA-PCR

PNA-PCR

Wild-Type (%)

113 (47)

53 (22)

166

·456

<0 · 001

Mutated (%)

12 (5)

64 (26)

76

  

Total

125

117

242

  
  1. *Kappa test was used to estimate the concordance of KRAS status between tumor tissue and plasma samples.
  2. †All Wald statistical tests were two-sided.
  3. PNA-PCR, peptide-nucleic-acid-mediated polymerase chain reaction clamping.