Early B-cell factor 3 (EBF3) is a novel tumor suppressor gene with promoter hypermethylation in pediatric acute myeloid leukemia

Table 2 Association of EBF3 promoter methylation with clinico-pathological characteristics in 105 pediatric AML samples

Clinical variables	No. of patients	*EBF3* methylation (n)		P
Clinical variables	No. of patients	Negative	Positive	P
Gender
Male	42	28	14	0.107
Female	63	32	31
Age (years)
<6	60	35	25	0.776
≥6	45	25	20
Leukocyte (/μl)
>10000	61	35	26	0.954
≤10000	44	25	19
FAB
M1-M6	93	55	38	0.250
M7	12	5	7
Cytogenetics
Favorable	50	27	23	0.060
Intermediate	27	12	15
Unfavorable	28	21	7
MRD
<0.25%	49	28	21	1.000
≥0.25%	56	32	24

ISSN: 1756-9966