Table 4 Cox multivariate analysis of EBF3 expression/promoter methylation and clinico-pathological features in pediatric AML

Cytogenetics

Favo vs. Inter and Unfavo

8.132

3.246(1.445-7.290)

0.004

MRD

<0.25% vs. ≥0.25%

12.951

5.496(2.173-13.901)

0.000

Leukocyte (/μl)

>10000 vs. ≤ 10000

1.371

1.433 (0.785-2.618)

0.242

FAB classification

M7 vs. M1-M6

4.301

2.379(1.049-5.397)

0.038

EBF3 Expression

Low vs. High

0.882

0.732(0.382-1.403)

0.348

EBF3 Methylation

Negative vs. Positive

0.317

1.201 (0.635-2.272)

0.574