Table 3 Cumulative effect of favorable and unfavorable genotypes on ovarian cancer risk
Analysis | Polymorphisms | Number of variants | Controls n (%) | Cases n (%) | OR (±95%CI) | P |
|---|---|---|---|---|---|---|
Favorable effect | p.Arg952Lys ATP7B | 0 | 52 (15.7) | 46 (23.78) | 1 (ref) | Â |
p.Arg72Pro TP53 | 1 | 162 (48.8) | 96 (49.5) | 0.67 (0.42-1.07) | 0.095 | |
| Â | 2 | 118 (35.5) | 52 (26.8) | 0.50 (0.30-0.83) | 0.008 | |
Unfavorable effect | p.Ile1145 = ABCB1 | 0 | 27 (8.1) | 3 (1.06) | 1 (ref) |  |
p.Asp1853Asn ATM | 1 | 95 (28.6) | 42 (22.3) | 3.98 (1.13-13.97) | 0.030 | |
p.Ser406Ala ATP7B | 2 | 163 (49.1) | 104 (55.3) | 5.74 (1.69-19.50) | 0.005 | |
3 | 47 (14.2) | 39 (20.8) | 7.47 (2.08-26.85) | 0.002 |