Figure 2

Effect of miR-203 on PCa cells and regulation of the Rac1/PAK1 pathway. (A) Relative expression of miR-203 in PC-3 and DU145 cells after infection with miR-203 as determined by qRT-PCR. (B) Cell viability was determined by the CCK-8 in both PC-3 and DU145 cells at the indicated time. (C) Cell adhesion abilities were assessed in both PC-3 and DU145 cells with or without forced expression of miR-203. (D) The migration capacity was assessed in both PC-3 and DU145 cells with or without forced expression of miR-203. (E) Western blot analysis shows the expression of RAC-1, PAK1, p-PAK1, MEK1and p-MEK1 after the ectopic expression of miR-203. * p < 0.05, ** p < 0.01.