Figure 6

CCAT1 promotes HCC progression by competitively binding let-7. (A) The mutation of let-7 binding sites attenuated the promoting proliferation effect of CCAT1 in SMMC-7721 cells. Cell number was determined by the CCK-8 assay, and the relative number of cells to 0 h is presented. (B) The mutation of let-7 binding sites attenuated the promoting migration effect of CCAT1 in SMMC-7721 cells by transwell assays. (C) Repression of let-7 overcame the inhibitory effects of decreasing CCAT1 on cell proliferation by the CCK-8 assay. (D) Repression of let-7 overcame the inhibitory effects of decreasing CCAT1 on cell migration by transwell assays. All values are presented as mean ± standard error based on at least three independent experiments. **p < 0.01, ***p < 0.001.