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Figure 5 | Journal of Experimental & Clinical Cancer Research

Figure 5

From: Nectin-4 expression contributes to tumor proliferation, angiogenesis and patient prognosis in human pancreatic cancer

Figure 5

Relationships between Nectin-4 expression and angiogenesis in human pancreatic cancer. (A) Positive correlation between Nectin-4 and VEGF expression in human pancreatic cancer by quantitative real-time PCR (n = 38, R = 0.566, P < 0.001, Spearman’s rank test). (B) Representative immunohistochemical staining of CD31 in human pancreatic cancer tissues. Original magnification × 200. (C) There was a significant correlation between the percent of positive Nectin-4 and intratumoral microvessel density (R = 0.254, P = 0.005, Spearman’s rank test). (D) The intratumoral microvessel density in the tumors with high Nectin-4 status was significantly higher than that in the tumors with low Nectin-4 status (*P =0.001, Mann-Whitney U test).

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