Figure 1

Core miRNA-gene network, including 8 key miRNAs and their targets. Hierarchical clustering analysis of 27 miRNAs (A) and 32 genes (B) that were differentially expressed between metastatic tissues in the peritoneal and paired primary samples of GC (greater than 2.0-fold; p < 0.05). Expression values are represented in shades of red and green, indicating expression above and below the median expression value across all samples. (C) The miRNA-gene network shows the relationships between 8 key miRNAs and tumor-associated genes they are predicted to regulate. The colors indicate the annotated expression levels of the miRNAs and genes.