The relevance of cell type- and tumor zone-specific VEGFR-2 activation in locally advanced colon cancer

Table 1 Percentage distribution of the VEGFR-2 ligands VEGF-C and VEGF-D in tumor cells of CC tissue

	Score	N0/M0	N+	M+	CC
		%	%	%	%
Tumor center
	0	37	33	34	35
VEGF-C	1	34	42	57	65
	2	29	25	9	65
	0	39	50	54	48
VEGF-D	1	50	50	33	52
	2	11	0	13	52
Tumor budding
	0	35	35	16	29
VEGF-C	1	35	40	74	71
	2	30	25	10	71
	0	33	50	52	45
VEGF-D	1	63	50	39	55
	2	4	0	9	55

The intensity of the tumoral staining was scored on a semiquantitative scale from 0 to 2 for the investigated biomolecule (0: no staining, 1: weak staining, 2: strong staining). For the statistical analysis using Fisher’s exact test the examined cases were separated into two groups, characterized by a negative/positive expression for VEGF-C and VEGF-D. The line in the staining intensity column indicates this dichotomization for each biomolecule. There were no significant differences between the groups

ISSN: 1756-9966