Table 1 General characteristics of included studies (about the relationships between CD133 expression and OS or PFS in glioma patients)
First author | Year | Origin country | No. of patients | Median/mean age (year) | WHO grade | Detect method | Cut off level | Survival end points | Follow up period | Survival analysis | Adjusted variables |
|---|---|---|---|---|---|---|---|---|---|---|---|
Ardebili [10] | 2011 | Slovenia | 24 | mean 60 | IV | QRT-PCR | 30 000 (─, 2-ΔΔCt > 30.000) | OS | NR | univariate (KM) | NR |
Kase [11] | 2013 | Estonia | 42 | 30–77 | IV | IHC | median | OS | NR | multivariate | Radiotherapy dose, Chemotherapy, Karnofsky performance score |
Kim [12] | 2011 | Korea | 88 | mean 54.9 (13–80) | IV | IHC | 50 % | OS | mean 13.9 months (1–53) | multivariate | age, sex, Karnofsky performance scale (KPS) score, extent of removal, chemoradiotherapeutic modality, temozolomide modality, after temozolomide therapy and stem cell marker expression |
PFS | |||||||||||
Melguizo [13] | 2012 | Italy | 75 | 24–81 | IV | IHC | 25 % | OS | NR | multivariate (KM) | NR |
PFS | |||||||||||
Metellus [14] | 2011 | France | 48 | mean 60.1 ± 9.2 | IV | QPCR | 1.03 | OS | Median 18.9 months | multivariable | Age, extent of surgery, MGMT status (MethyLight) |
PFS | |||||||||||
Shibahara [15] | 2013 | Japan | 112 | Media 57 (7–77) | IV | WB | CD133/b-actin ratio = 1 | OS | Median 25.7 months (3–152) | multivariable | Ki67 LI (≥35 %), 9p homozygous deletion and 10q loss |
Shin [16] | 2013 | Korea | 67 | NR | IV | IHC | 50 % | OS | NR | multivariable | status |
PFS | |||||||||||
Zeppernik [17] | 2008 | Germany | 48 | NR | II–III | IHC | 1 % | OS | mean 86 months (±39) | multivariate | age, WHO grade and extent of resection |
PFS | |||||||||||
Dahlrot [18] | 2014 | Denmark | 25 | NR | II | IF | median | OS | Media 12 months | multivariate | age, performance status (PS) and IDH1 status |
PFS | |||||||||||
Dahlrot [18] | 2014 | Denmark | 26 | NR | III | IF | median | OS | Media 12 months | multivariate | age, performance status (PS) and IDH1 status |
PFS | |||||||||||
Dahlrot [18] | 2014 | Denmark | 185 | NR | IV | IF | median | OS | Media 12 months | multivariate | age, performance status (PS) and IDH1 status |
PFS |