Fig. 4

Downregulation of ARID1A increases in vivo xenograft tumor growth. a Images of xenografts in ARID1A knockdown group (bottom) and control group (top) at the end of the experiment. Control shRNA and ARID1A shRNA cells were injected subcutaneously into nude mice (n = 8 for each group), and the tumors were isolated 8 weeks later. b ARID1A knockdown promotes xenograft growth of MHCC-97H cells in nude mice (n = 6, P < 0.005). c Silencing ARID1A in HCC cells promotes its lung metastasis, left panel shows the HE image of mouse lung tissue in control group, right panel exhibits the HE image of mouse lung tissue with HCC metastasis, indicated by the black arrow