Fig. 4From: Confrontation of fibroblasts with cancer cells in vitro: gene network analysis of transcriptome changes and differential capacity to inhibit tumor growthFunctional relations of differentially expressed genes with each other and with members of important pathways, as displayed by FunCoup online resource [14]. a Genes differentially expressed under confrontation with tumor cells and pathway members. Nodes: Yellow, genes of the proinflammatory signature [27], and/or YAP/TAZ cascade [25], and/or Hippo pathway [26]. Red, confrontation-specific DEGs. Orange: genes that belong to both “yellow” and “red” categories Line color denotes origin of FunCoup evidence for the network edges (see also “Global interaction network” in Methods): Red, protein-protein interactions. Blue: co-expression of mRNA. Deep green: links in a KEGG pathway. Multiple lines between the same two nodes indicate that multiple lines of evidence and were treated as single edges in NEA. Lines with FunCoup confidence <0.1 for the individual component are not shown. b Genes differently expressed between 4 most and 4 least inhibitory fibroblast cultures before confrontation and pathway members. Yellow: the RhoA signaling pathway by PID database [30] and pathway for RhoD regulation of cytosceletal dynamics via WHAMM [31]. Red, DEGs between inhibitory and non-inhibitory fibroblast samples. The the line color, see the legend in ABack to article page