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Table 3 Clinic pathological characteristics of HPV-positive and HPV-negative patients with ESCC

From: Heterozygote of TAP1 Codon637 decreases susceptibility to HPV infection but increases susceptibility to esophageal cancer among the Kazakh populations

Characteristics Number HPV+ Patients n = 204 HPV Patients n = 112 χ 2 P value
n (%) n (%)
Age (years), mean ± SD 316 53.01 ± 8.202 52.67 ± 10.141   0.746a
Age (years)     0.301 0,584
 <55 173 114 (65.9) 59 (34.1)   
 ≥55 113 90 (62.9) 53 (37.1)   
Gender     2.692 0,101
 Male 187 127 (67.9) 60 (32.1)   
 Female 129 76 (58.9) 53 (41.1)   
Smoking     0.081 0.775
 Yes 82 54 (65.9) 28 (34.1)   
 No 234 150 (64.1) 84 (35.9)   
Drinking     2.149 0.143
 Yes 65 47 (72.3) 18 (27.7)   
 No 251 157 (62.5) 94 (37.5)   
Location of the tumor     1.311 0.519
The upper thoracic portion 19 10 (52.6) 9 (47.4)   
The mid-thoracic portion 170 112 (65.9) 58 (34.1)   
The lower thoracic portion 127 82 (64.6) 45 (35.4)   
Histologic grade     0.331 0.848
Well-differentiated (G1) 106 67 (63.2) 39 (36.8)   
Moderately differentiated (G2) 162 107 (66.0) 55 (34.0)   
Poorly differentiated (G3) 48 30 (62.5) 18 (37.5)   
Depth of invasion     0320 0.572
T1/T2 188 119 (63.3) 69 (36.7)   
T3/T4 128 85 (66.4) 43 (33.6)   
Lymph node metastasis     1.127 0.288
No 193 129 (66.8) 64 (33.2)   
Yes 123 75 (61.0) 48 (39.0)   
Clinical stage     1.847 0.174
stage I/II 231 144 (62.3) 87 (37.7)   
stage III/IV 85 60 (70.6) 25 (29.4)   
  1. aStudent’s test