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Table 4 Association of TAP1 gene polymorphisms with risk of Kazakh ESCC

From: Heterozygote of TAP1 Codon637 decreases susceptibility to HPV infection but increases susceptibility to esophageal cancer among the Kazakh populations

Genotype or allele Case n (%) Control n (%) P value OR (95 % CI)
TAP1 D637G     
 AAa 73 (48.7) 173 (61.1)   1.000 (reference)
 AG 70 (46.7) 102 (36.1) 0.019 1.626 (1.080–2.449)
 GG 7 (4.7) 8 (2.8) 0.246b 2.074 (0.725–5.930)
Combined variant genotypes     
 AG + GG 77 (51.3) 110 (38.9) 0.013 1.659 (1.112–2.474)
 Aa 216 (72.0) 448 (79.2)   1.000 (reference)
 G 84 (28.0) 118 (20.8) 0.018 1.477 (1.068–2.040)
TAP1 I333V     
 AAa 82 (54.7) 134 (47.3)   1.000 (reference)
 AG 62 (41.3) 130 (46.0) 0.232 0.780 (0.518–1.173)
 GG 6 (4.0) 19 (6.7) 0.170 0.516 (0.198–1.345)
Combined variant genotypes     
 AG + GG 68 (45.3) 149 (52.7) 0.112 0.724 (0.486–1.079)
 Aa 226 (72.0) 398 (70.3)   1.000 (reference)
 G 74 (24.7) 168 (29.7) 0.118 0.776 (0.564–1.067)
  1. aReference group
  2. bFisher’s exact test