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Table 6 Stratification analysis to evaluate the association of HPV positive patients with TAP1 polymorphisms in Kazakh ESCC by tumor depth

From: Heterozygote of TAP1 Codon637 decreases susceptibility to HPV infection but increases susceptibility to esophageal cancer among the Kazakh populations

Parameters TAP1 D637G (HPV+/HPV- patients) OR (95 % CI) TAP1 I333V (HPV+/HPV- patients) OR (95 % CI)
AAa AG/GG AAa AG/GG
Tumor depth       
T1/T2 21/16 13/35 0.283 (0.114–0.703)** 23/27 11/24 0.538 (0.218–1.330)
T3/T4 27/9 14/15 0.311 (0.109–0.888)* 21/11 20/13 0.806 (0.294–2.212)
T1-T4 48/25 48/25 0.281 (0.144–0.551)*** 44/38 31/37 0.724 (0.380–1.380)
  1. “*”represents P < 0.05, “**”indicates P < 0.01, “***”depicts P < 0.001
  2. aReference group. We consider the common homozygotes of TAP1 as ORs of 1.00 for the reference genotype