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Table 2 Efficacy summary (n = 94)

From: Intermittent high dose proton pump inhibitor enhances the antitumor effects of chemotherapy in metastatic breast cancer

No. (%)

ORR (%)

mTTP (months) (95 % CI)

mOS (months) (95 % CI)

Arm A (no ESOM) (n = 32)

46.9

8.7 (6.8-10.6)

19.2 (10.1-28.3)

Arm B (lower dose ESOM (n = 31)

71.0

9.4 (5.8-13.1)

39.3 (31.6-47.1)

Arm C (higher dose ESOM (n = 31)

64.5

9.7 (7.8-11.6)

26.1 (21.1-31.1)

Arm B + C (Combined(n = 62)

67.7

9.7 (7.6-11.8)

29.9 (22.3-37.4)

  1. ESOM esomeprazole, ORR overall response rate, mTTP median time to progression, mOS median over survival