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Fig. 5 | Journal of Experimental & Clinical Cancer Research

Fig. 5

From: Therapeutic potential of antiviral drugs targeting chemorefractory colorectal adenocarcinoma cells overexpressing endogenous retroviral elements

Fig. 5

Isobologram showing the in vitro interaction between amantadine and doxorubicin, cisplatin or 5FU in HCT8WT and HCT8RETO cells. Dose-response curves are based on the respective IC50 values calculated after 24 hours of incubation. Amantadine-doxorubicin are synergistic in HCT8 WT/RETO (a & b). Amantadine-cisplatin are additive in HCT8 wildtype (c) and synergistic in HCT8RETO (d). Amantadine-5FU are synergistic in RETO (f) but antagonistic in HCT8WT (e). n = 3 independent experiments

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