Fig. 4

Ectopic expression of miR-195 inhibits tumor growth and metastasis via targeting BCOX1 in vivo. Restoration of BCOX1 significantly reversed the suppression of tumor growth and metastasis induced by miR-195. a and b, Ectopic expression of miR-195 in PCa cells significantly inhibits tumor growth in a mouse xenograft model. c and d, Tumor weights of corresponding mouse xenograft models. e and f, BCOX1 expression analysis was performed at protein level by immunochemistry. g and h, BCOX1 expression analysis was conducted at protein level by western blot. I, miR-195 played an important role in PCa metastasis in vivo via targeting BCOX1