Fig. 5From: Resistance to multikinase inhibitor actions mediated by insulin like growth factor-1MAPK signaling and IGFR1 expression in PLC/PRF/5 cells. a. Western blot of MAPK proteins that shows IGF1 antagonism effect on Regorafenib action in PLC/PRF/5 cells. b. Activated IGF1 receptor (IGFR1) after treatment with Regorafenib (R), IGF1, IGF1 + R, IGF1 + GSK and IGF1 + R + GSK, respectively. c. IGF1 effect on the BRAF protein that is direct Regorafenib targetBack to article page