DDR2 facilitates hepatocellular carcinoma invasion and metastasis via activating ERK signaling and stabilizing SNAIL1

Table 1 Correlations between DDR2 expression and clinicopathologic features in HCC

Characteristics	n	DDR2 expression		P value
Characteristics	n	High	Low	P value
Gender
Female	25	15	10
Male	87	41	46	0.364
Age (year)
≤ 45	29	10	19
> 45	83	46	37	0.083
HBsAg status^a
Negative	22	7	15
Positive	90	49	41	0.095
Cirrhosis
No	37	15	22
Yes	75	41	34	0.228
AFP (μg/l)^b
≤ 400	55	23	32
> 400	57	33	24	0.130
Tumor size
≤ 5 cm	37	14	23
> 5 cm	75	42	33	0.107
Tumor number
Single	86	37	49
Multiple	26	19	7	0.013^*
Tumor capsule
Complete	20	7	13
Incomplete	92	49	43	0.217
Vascular invasion
No	86	36	50
Yes	26	20	6	0.003^*
Edmondson grade
I/II	64	24	40
III/IV	48	32	16	0.004^*
TNM stage
I/II	67	25	42
III/IV	45	31	14	0.002^*

ISSN: 1756-9966