Fig 2

CD15/FUT4 expression pattern, inflammatory response and patients’ outcome in a larger cohort study. a Significant inverse correlation of NLR at diagnosis with tumor-associated CD3⁺ T-cells and CD8⁺ T- cytotoxic quantification (n = 99; expressed as mean of replicates cells counts, cells mm⁻²). b Correlation between NLR at diagnosis and tumor-related expression pattern of CD15/FUT4 spared into three subgroups negative, low and high, respectively. One dot represents NLR at diagnosis for each patient, P value was obtained by Mann–Whitney test. c Kaplan–Meier curves for progression-free survival and overall survival in the validation set (n = 102). The medians PFS value were 13, 10 and 5.5 months (HR = 3.37; 95 % CI = 2.14–5.51). The medians OS value were 38, 26 and 13 months for negative (n = 18), low (n = 40) and high-CD15/FUT4 (n = 44) expressing tumors, respectively (HR = 1.95; 95 % CI = 1.37–2.98). d Kaplan–Meier curves for progression-free survival and overall survival in relationship with NLR at diagnosis (cutoff value of 5). The medians PFS value were 12 and 6.5 months respectively (HR = 2.41; 95 % CI = 1.37–4.32). The medians OS value were 35 and 17 months with an NLR ≤5 (n = 30) and an NLR >5 (n = 72) patients respectively(HR = 2.39; 95 % CI = 1.48–3.85)