Fig. 1

IL-6 increases the level of HCC specific lncRNA mRNA in HCC cells. a Relative mRNA levels of HCC specific lncRNAs in SK-Hep1 cells treated with IL-6 50 ng/ml for 24 h (normalized to GAPDH). b Treatment of SK-Hep-1 cells with IL-6 induced the expression of lncTCF7 in a time- and dose-dependent manner. qRT-PCR analysis of lncTCF7 in SK-Hep-1 cells incubated with gradient concentrations of IL-6 for 24 h. qRT-PCR analysis of lncTCF7 in SK-Hep-1 cells incubated with IL-6 50 ng/ml for different periods of time. c Similar to effects seen in SK-Hep-1 cells, IL-6 also induced the expression of lncTCF7 in BEL-7402 cells. Data represent the mean ± S.D. from three independent experiments.*p < 0.05.*p < 0.05