Fig. 6

CMTM4 inhibits the tumourigenicity of 786-O cells ex vivo. a A representative nude mouse (left) showing the different morphologies of the tumours derived from the Ad-CMTM4-infected 786-O cells and Ad-null-infected control cells. The tumours were then dissected and photographed (right). The growth curve (b) and average weight (c) of the CMTM4-expressing tumours versus the control tumours are expressed as the means ± SEM for each group (n = 6). *, P < 0.05; **, P < 0.01; and ***, P < 0.001. d The expression of CMTM4 and p21 in the tumour xenografts was detected by western blotting. β-actin was used as an internal standard. A representative result of the tumours from one mouse (left) and the average relative intensity of p21 with the SEM from 6 mice (right) are shown. *, P < 0.05