Fig. 6
Tivantinib abrogates tumor growth in MHCC97L xenograft mouse model independent of inhibition MET. a Tivantinib does not inhibit phosphorylation of MET in MHCC97L tumors demonstrated by immunohistochemical and Western blot analyses. b The picture of the excised MHCC97L tumor from mice receiving different concentration of tivantinib treatment. c The changes in tumor volume over the time course of the experiment in MHCC97L xenograft model are shown. Each point on the line graph represents the mean tumor volume (mm3) on the corresponding day over the time course of the experiment. d The mean of tumor weights of the excised MHCC97L tumor from different mice. Each column represents the mean of the determinations. e Changes in the mean of body weight over the time course of the experiment in MHCC97L xenograft model are shown. Each point on the line graph represents the mean of the body weight on a particular day. Scale bars, 100 μm. *, P < 0.05 vs. the control group