Fig. 7

Effects of tivantinib on cell proliferation and apoptosis of MHCC97H xenografts. Mice bearing tumor xenografts were treated as described in Materials and Methods. a Proliferative cells stained with anti-Ki-67 antibody in tumors. b Apoptotic cells determined by TUNEL assay in tumors. The bar graph, mean ± SD of quantification of Ki-67 and TUNEL-labelled positive cells from analysis of tumors. Scale bars, 100. *, P < 0.05