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Table 3 Univariate analysis of the DFS and OS in 195 colon cancer patients

From: Karyopherin alpha 2 is a novel prognostic marker and a potential therapeutic target for colon cancer

Variable

DFS

OS

 

HR

95 % CI

p

HR

95 % CI

p

Age (years)

  < 65

  > 65

0.958

0.581–1.547

0.832

1.048

0.581–1.888

0.877

Sex

 male

      

 female

0.959

0.593–1.552

0.865

1.227

0.681–2.212

0.496

Location

 right

      

 others

1.143

0.957–1.365

0.139

1.159

0.936–1.436

0.176

AJCC stage

 I + II

      

 III + IV

3.248

2.256–4.675

<0.001*

15.219

4.281–54.102

<0.001*

T stage

 T1 + T2

      

 T3 + T4

1.638

1.160–2.313

0.005*

1.226

0.846–1.777

0.282

N stage

 N0

      

 N1 + N2

3.293

2.413–4.494

<0.001*

2.569

1.773–3.724

<0.001*

M stage

M0

      

M1

5.641

2.661–11.958

<0.001*

8.713

3.786–20.055

<0.001*

Differentiation

 Well + moderate

      

 Poor

1.404

1.010–1.952

0.043

1.363

0.915–2.032

0.128

Vascular invasion

 no

      

 Yes

4.356

2.266–8.35

<0.001*

3.705

1.646–8.337

0.002*

Ki–67 expression

 low

      

 high

1.311

0.952–1.084

0.097

0.924

0.659–1.295

0.646

KPNA2 expression

 low

      

 high

1.969

1.410–2.748

<0.001*

1.729

1.158–2.583

0.007*

  1. HR hazard ratio, CI confidence interval. *p < 0.005 indicates that the lower limit of the 95 % CI of HR is >1