From: Karyopherin alpha 2 is a novel prognostic marker and a potential therapeutic target for colon cancer
Variable | DFS | OS | ||||
---|---|---|---|---|---|---|
HR | 95 % CI | p | HR | 95 % CI | p | |
Age (years) | ||||||
< 65 | ||||||
> 65 | 0.958 | 0.581–1.547 | 0.832 | 1.048 | 0.581–1.888 | 0.877 |
Sex | ||||||
male | ||||||
female | 0.959 | 0.593–1.552 | 0.865 | 1.227 | 0.681–2.212 | 0.496 |
Location | ||||||
right | ||||||
others | 1.143 | 0.957–1.365 | 0.139 | 1.159 | 0.936–1.436 | 0.176 |
AJCC stage | ||||||
I + II | ||||||
III + IV | 3.248 | 2.256–4.675 | <0.001* | 15.219 | 4.281–54.102 | <0.001* |
T stage | ||||||
T1 + T2 | ||||||
T3 + T4 | 1.638 | 1.160–2.313 | 0.005* | 1.226 | 0.846–1.777 | 0.282 |
N stage | ||||||
N0 | ||||||
N1 + N2 | 3.293 | 2.413–4.494 | <0.001* | 2.569 | 1.773–3.724 | <0.001* |
M stage | ||||||
M0 | ||||||
M1 | 5.641 | 2.661–11.958 | <0.001* | 8.713 | 3.786–20.055 | <0.001* |
Differentiation | ||||||
Well + moderate | ||||||
Poor | 1.404 | 1.010–1.952 | 0.043 | 1.363 | 0.915–2.032 | 0.128 |
Vascular invasion | ||||||
no | ||||||
Yes | 4.356 | 2.266–8.35 | <0.001* | 3.705 | 1.646–8.337 | 0.002* |
Ki–67 expression | ||||||
low | ||||||
high | 1.311 | 0.952–1.084 | 0.097 | 0.924 | 0.659–1.295 | 0.646 |
KPNA2 expression | ||||||
low | ||||||
high | 1.969 | 1.410–2.748 | <0.001* | 1.729 | 1.158–2.583 | 0.007* |