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Table 3 Univariate analysis of the DFS and OS in 195 colon cancer patients

From: Karyopherin alpha 2 is a novel prognostic marker and a potential therapeutic target for colon cancer

Variable DFS OS
  HR 95 % CI p HR 95 % CI p
Age (years)
  < 65
  > 65 0.958 0.581–1.547 0.832 1.048 0.581–1.888 0.877
Sex
 male       
 female 0.959 0.593–1.552 0.865 1.227 0.681–2.212 0.496
Location
 right       
 others 1.143 0.957–1.365 0.139 1.159 0.936–1.436 0.176
AJCC stage
 I + II       
 III + IV 3.248 2.256–4.675 <0.001* 15.219 4.281–54.102 <0.001*
T stage
 T1 + T2       
 T3 + T4 1.638 1.160–2.313 0.005* 1.226 0.846–1.777 0.282
N stage
 N0       
 N1 + N2 3.293 2.413–4.494 <0.001* 2.569 1.773–3.724 <0.001*
M stage
M0       
M1 5.641 2.661–11.958 <0.001* 8.713 3.786–20.055 <0.001*
Differentiation
 Well + moderate       
 Poor 1.404 1.010–1.952 0.043 1.363 0.915–2.032 0.128
Vascular invasion
 no       
 Yes 4.356 2.266–8.35 <0.001* 3.705 1.646–8.337 0.002*
Ki–67 expression
 low       
 high 1.311 0.952–1.084 0.097 0.924 0.659–1.295 0.646
KPNA2 expression
 low       
 high 1.969 1.410–2.748 <0.001* 1.729 1.158–2.583 0.007*
  1. HR hazard ratio, CI confidence interval. *p < 0.005 indicates that the lower limit of the 95 % CI of HR is >1