Fig. 3
Characteristics of rNDV-18HL. a Proliferation dynamic of rNDV-18HL. BHK-21 cells were infected with either rNDV-18HL or NDV Italien at MOI = 0.01. At 6, 12, 24, 36, 48, and 72 h post-infection, culture supernatants were collected and the viral titer was determined (TCID50/ml) (n = 3). b Cytotoxicity assay of rNDV-18HL. SMMC-7721, HuH-7, and HuH-7 cells were infected with either rNDV-18HL or NDV Italien for 7 days. The cell viability was measured using MTT assay (n = 5). The cell viability of the three HCC cell lines at 7 days post-infection was shown in (c)