Table 1 PEDF functional domains
Function | Peptide sites |
|---|---|
Anti-angiogenesis | 34-mer peptide region (residues 24–57) |
Collagen binding (anti-angiogenesis) | Asp256,Asp258, Asp300 (negatively charged), Arg149, Lys166, Lys167 (positively charged). Asp255, Asp257 and Asp299 are critical to collagen-I-binding |
Cell differentiation | 44-mer peptide region (residues 58–101) |
Heparin binding | Arg145, Lys146 and Arg148 |
Hyaluronan | Lys189, Lys191, Arg194 and Lys197 form a motif that is critical for hyaluronan binding (Becerra et al. [42]) |
Laminin binding | 34-mer peptide region (residues 44–77) (Bernard et al. [46]) |
Phosphorylation | Ser24, Ser114, Ser227 |
Neurotrophy | 44-mer peptide region (residues in humans 78–121) |
Tumor cell apoptosis | 34-mer peptide region (residues 24–57) |