Tumor-associated macrophages correlate with the clinicopathological features and poor outcomes via inducing epithelial to mesenchymal transition in oral squamous cell carcinoma

Table 1 Correlation between clinical parameters and CD68+ macrophages counts in tumor nest and tumor stroma

Variable	No.	CD68+ macrophages counts in tumor nest			CD68+ macrophages counts in tumor stroma
Variable	No.	Low(≤6/HPF)	High(>6/HPF)	P	Low(≤8/HPF)	High(>8/HPF)	P
Sex				0.176			0.060
Male	74	34	40		30	44
Female	53	18	35		13	40
Age (years)				0.773			0.927
≤50	26	10	16		9	17
>50	101	42	59		34	67
Tumor location				0.034			0.346
Tongue	52	29	23		20	32
Gingiva	26	7	19		8	18
Buccal mucosa	31	8	23		6	25
Lip	4	3	1		2	2
Floor of the mouth	2	1	1		1	1
Others	12	4	8		6	6
Tumor size				0.665			0.369
T1	21	9	12		7	14
T2	68	28	40		21	47
T3	26	12	14		8	18
T4	12	3	9		7	5
Lymph node metastasis				0.850			0.321
N0	72	30	42		27	45
N (+)	55	22	33		16	39
Metastasis				0.793			0.627
M0	125	51	74		42	83
M (+)	2	1	1		1	1
Clinical stage				0.262			0.699
I	12	5	7		4	8
II	42	19	23		17	25
III	34	16	18		8	26
IV	39	12	27		14	25
Pathological grade				0.135			0.296
I	76	34	42		24	52
II	42	18	24		13	29
III	9	0	9		6	3
Recurrence				0.111			0.259
No	83	39	44		25	58
Yes	42	13	29		18	24
Lost	2	0	2		0	2
Follow-up				0.005			0.218
Live	91	45	46		27	64
Dead	33	7	26		15	18
Lost	3	0	3		1	2

No., number of patients; HPF, high-power field. N0, no lymph node metastasis; N (+), node metastasis. M0, no metastasis; M(+), metastasis
Bold values signify P < 0.05

ISSN: 1756-9966