Tumor-associated macrophages correlate with the clinicopathological features and poor outcomes via inducing epithelial to mesenchymal transition in oral squamous cell carcinoma

Table 2 Correlation between clinical parameters and CD163⁺ macrophages counts in tumor nest and tumor stroma

Variable	No.	CD163+ macrophages counts in tumor nest			CD163+ macrophages counts in tumor stroma
Variable	No.	Low(≤6/HPF)	High(>6/HPF)	P	Low(≤8/HPF)	High(>8/HPF)	P
Sex				0.037			0.846
Male	74	36	38		32	42
Female	53	16	37		22	31
Age (years)				0.874			0.674
≤50	26	11	15		12	14
>50	101	41	60		42	59
Tumor location				0.389			0.057
Tongue	52	24	28		22	30
Gingiva	26	9	17		17	9
Buccal mucosa	31	9	22		7	24
Lip	4	3	1		2	2
Floor of the mouth	2	1	1		1	1
Others	12	6	6		5	7
Tumor size				0.921			0.335
T1	21	7	14		7	14
T2	68	31	37		30	38
T3	26	8	18		9	17
T4	12	6	6		8	4
Lymph node metastasis				0.200			0.889
N0	72	33	39		31	41
N (+)	55	19	36		23	32
Metastasis				0.235			0.829
M0	125	52	73		53	72
M (+)	2	0	2		1	1
Clinical stage				0.059			0.725
I	12	5	7		4	8
II	42	21	21		21	21
III	34	16	18		13	21
IV	39	10	29		16	23
Pathological grade				0.211			0.469
I	76	35	41		35	41
II	42	13	29		14	28
III	9	4	5		5	4
Recurrence				0.22			0.01
No	83	38	45		28	55
Yes	42	13	29		24	18
Lost	2	1	1		2	0
Follow-up				0.04			0.040
Live	91	43	48		34	57
Dead	33	8	25		17	16
Lost	3	1	2		3	0

No., number of patients; HPF, high-power field. N0, no lymph node metastasis; N (+), node metastasis. M0, no metastasis; M(+), metastasis
Bold values signify P < 0.05

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