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Table 1 Comparison between gene ontology results of MLL-AF9 dependently expressed genes and miRNA target genes

From: The leukemogenic fusion gene MLL-AF9 alters microRNA expression pattern and inhibits monoblastic differentiation via miR-511 repression

 

Gene expression

Known miRNA targets

Predicted miRNA targets

DNA replication

×

Ø

×

apoptosis

×

×

Ø

cell cycle

Ø

×

×

JAK-STAT signaling

×

Ø

×

Wnt signaling

Ø

×

×

cytokine

×

×

Ø

endocytosis

×

Ø

×

adhesion

Ø

×

×

lysosome

×

Ø

×

myeloid differentiation

Øa

×

×

hemopoiesis

×

×

Ø

transcription factor

×

×

×

reg of pol II transcription

×

×

×

cell size

×

×

Ø

cellular response to stress

Ø

×

×

  1. Compared were the gene ontology results obtained via DAVID software between MLL-AF9 dependently expressed genes [7] and known (miRTarBase) as well as predicted (TargetScan) target genes of MLL-AF9 dependently expressed miRNAs. × present in the data set, Ø not present in the data set
  2. arefers to gene ontology terms directly concerning myeloid differentiation (e.g. “regulation of myeloid cell differentiation”), whereas terms indirectly related to myeloid differentiation (e.g. “phagocytosis”) were also present within the gene expression profile. Terms in bold letters were preferentially present in the miRNA target gene data sets