Fig. 7

NRP-1 structure and a proposed model of interactions of NRP-1 as multifunctional co-receptors with VEGF/VEGFR2, EGF/EGFR and HGF/c-MET pathways in gastric cancer cells. NRP-1 molecule consists of five extracellular domains, a single-pass transmembrane domain (TMD) and a short cytosolic tail. “→” indicates promotion, positive regulation or activation; “⊥”, inhibition, negative regulation or blockade. A dotted line indicates uncertain mechanisms, while a solid line, identified mechanisms. Abbreviations: CDK, cyclin-dependent kinase; EGF, epithelial growth factor; EGFR, epithelial growth factor receptor; ERK, extracellular-signal-regulated kinase; FAK, focal adhesion kinase; HGF, hepatocyte growth factor; MEK, mitogen-activated protein kinase; NRP-1, neuropilin-1; VEGF, vascular endothelial growth factor; VEGFR, vascular endothelial growth factor receptor