Fig. 2

Overexpression of IL-37 suppresses NSCLC tumorigenesis in vivo. a qRT-PCR analysis of IL-37 mRNA expression from wild-type (WT), mock- transfected, and IL-37 transfected (clone 1 and 2) H1299 cells. b Western blot analysis of protein lysates from the cells. c ELISA analysis of IL-37 in supernatants of the cells. d Tumor volume during four weeks after the transplantation (n = 10 per group). e Tumor weights on week four after transplantation. Data shown are mean ± SD from three independent experiments. ^* P < 0.05, ^** P < 0.01, ^*** P < 0.001