Fig. 4

Aspirin augmented the efficacy of gemcitabine in vivo, however Lipitor weakened the efficacy of gemcitabine. a Panc02 pancreatic cancer cells were subcutanously implanted in the immunocompetent mice and then gemcitabine was intrperitoneally injected for chemotherapy. (a) The tumor growth curve indicated that aspirin augmented the efficacy of gemcitabine, on the contrary, Lipitor weakened the efficacy of aspirin and gemcitabine. b The final tumor weight confired the results of the tumor growth curver. c The general figure of fresh tumors were shown. d H&E staining of the necrosis lesions also confirmed the efficacy of aspirin and gemcitabine (×200). Each experiment was performed in triplicats and the representative one was shown. . ANOVA analysis, SNK-q test, ^* P < 0.05, ^** P < 0.01