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Table 2 The changes of inflammatory cell populations in peripheral blood and tumor tissue after chemotherapy (n = 5, %, Mean ± SEM)

From: Atorvastatin (Lipitor) attenuates the effects of aspirin on pancreatic cancerogenesis and the chemotherapeutic efficacy of gemcitabine on pancreatic cancer by promoting M2 polarized tumor associated macrophages

Population

Peripheral blood

Tumor tissue

 

Control

Chemotherapy

Control

Chemotherapy

Control

Chemotherapy

in inflammatory cells

in all cells

Th

12.21 ± 4.35

15.21 ± 3.37

15.26 ± 2.67

7.20 ± 2.00*

6.11 ± 1.07

2.25 ± 1.04*

CTL

9.45 ± 2.75

9.40 ± 2.75

10.53 ± 2.00

5.56 ± 1.57*

3.12 ± 0.73

1.01 ± 0.55*

B cell

25.54 ± 4.51

30.44 ± 5.23

10.70 ± 1.52

19.07 ± 2.56*

3.45 ± 1.01

6.28 ± 1.27*

Granulocyte

43.57 ± 6.72

37.56 ± 4.55

40.12 ± 6.41

38.56 ± 4.43

12.04 ± 3.27

10.44 ± 2.49

Mφ

10.11 ± 3.58

10.12 ± 2.46

16.61 ± 3.11

24.12 ± 4.12*

5.28 ± 0.76

8.14 ± 1.07*

DC

7.27 ± 2.12

16.45 ± 3.26*

8.13 ± 1.64

15.21 ± 2.12*

2.67 ± 1.22

4.77 ± 1.48*

NK

7.60 ± 1.12

6.55 ± 1.01

4.32 ± 1.12

3.31 ± 1.10

1.24 ± 0.52

1.05 ± 0.75

NKT

3.25 ± 0.44

2.27 ± 0.06

2.30 ± 0.24

3.32 ± 0.57

0.88 ± 0.16

0.75 ± 0.42

MDSC

25.22 ± 5.18

15.20 ± 3.10*

28.67 ± 3.32

18.75 ± 2.35*

7.44 ± 1.29

4.55 ± 0.92*

M1

9.67 ± 2.21

8.55 ± 2.01

7.36 ± 2.91

9.11 ± 2.12

2.46 ± 1.25

3.12 ± 1.09

M2

1.91 ± 1.58

5.11 ± 1.54*

10.97 ± 3.30

18.12 ± 3.56*

3.36 ± 0.70

5.98 ± 1.55*

  1. Th helper T cells, CTL cytotoxic T lymphocyte, Mφ monocyte & macrophage, DC dendritic cells, NK natural killer cells, NKT natural killer T cells, MDSC myeloid derived suppressor cells, M1 M1-polarized tumor associated macrophages M2, M2-polarized tumor assocaited macrophages. Paired Student t-test, * P < 0.05