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Table 3 The changes of the inflammatory cell populations in peripheral blood after chemotherapy (n = 6, %, mean ± SEM)

From: Atorvastatin (Lipitor) attenuates the effects of aspirin on pancreatic cancerogenesis and the chemotherapeutic efficacy of gemcitabine on pancreatic cancer by promoting M2 polarized tumor associated macrophages

Cell population

Peripheral blood

Control

Chemo.

Chemo. + ASP

Chemo. + Lip

Chemo. + ASP + LIP

Th

13.46 ± 3.33

12.01 ± 3.48

13.12 ± 2.16

12.98 ± 2.01

12.01 ± 1.30

CTL

10.44 ± 2.65

9.22 ± 2.65

8.11 ± 2.05

10.11 ± 3.44

9.40 ± 1.75

B cells

27.52 ± 5.01

26.04 ± 5.12

31.01 ± 5.01

22.24 ± 4.01

24.88 ± 6.27

Granulocyte

45.55 ± 7.71

32.33 ± 5.75

32.55 ± 4.66

35.46 ± 4.44

38.22 ± 4.77

Mφ

13.12 ± 3.44

17.11 ± 2.52

9.11 ± 2.05

13.11 ± 4.08

14.01 ± 3.58

DC

7.34 ± 2.06

15.42 ± 2.34*

17.77 ± 4.37*

15.88 ± 1.34*

18.24 ± 2.07*

NK

6.56 ± 2.18

7.50 ± 2.04

5.44 ± 1.25

6.80 ± 1.22

7.70 ± 1.22

NKT

2.29 ± 1.40

3.01 ± 1.26

3.01 ± 0.67

3.20 ± 0.67

3.80 ± 1.04

MDSC

23.21 ± 4.29

14.70 ± 3.14*

7.20 ± 2.45** #

16.01 ± 3.24*&

9.28 ± 1.24** #

M1

7.87 ± 2.88

10.85 ± 1.45

8.58 ± 3.44

9.05 ± 2.75

11.57 ± 2.76

M2

2.91 ± 1.58

7.11 ± 1.54*

3.01 ± 1.05#

11.01 ± 2.04** #

5.22 ± 1.77

  1. Th helper T cells, CTL cytotoxic T lymphocyte, Mφ monocyte & macrophage, DC dendritic cells, NK natural killer cells, NKT natural killer T cells, MDSC myeloid derived suppressor cells, M1 M1-polarized tumor associated macrophages, M2 M2-polarized tumor assocaited macrophages. Compared with Control group, * P < 0.05, ** P < 0.01; Compared with Chemo.group, # P < 0.05, ## P < 0.01; Compared with Chemo. + ASP group, & P < 0.05,&& P < 0.01; ANOVA analysis, SNK-q test
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Journal of Experimental & Clinical Cancer Research

ISSN: 1756-9966

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