Fig. 6
From: CD146 promotes metastasis and predicts poor prognosis of hepatocellular carcinoma
Western blotting vertification of the mechanism of CD146 induced metastasis. a CD146 induced ERK1/2 phosphorylation, IL-8 upregulation and STAT1 down regulation in HLF and 97 L cell lines (n = 3, **P < 0.01, ***P < 0.001). b Interfere CD146 inhibited ERK1/2 phosphorylation, induced IL-8 downregulation and STAT1 upregulation in 97H and 7721 cell lines (n = 3, **P < 0.01, ***P < 0.001). c CD146 induced EMT (E-cad downregulation, vimentin, slug upregulation ) in HLF and 97 L cell lines (n = 3, **P < 0.01, ***P < 0.001). d Interfere CD146 inhibited EMT in 97H and 7721 cell lines (n = 3, **P < 0.01, ***P < 0.001)