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Table 3 The relationship between CCR7 and the clinicopathological factors of GBC

From: CCR7 mediates the TNF-α-induced lymphatic metastasis of gallbladder cancer through the “ERK1/2 - AP-1” and “JNK - AP-1” pathways

Factors case number CCR7 χ 2 P value
- ~ ++ +++ ~ ++++
Age(year)     0.475 0.491
 <60 20 7 13
 ≥60 22 10 12
Gender     2.888 0.089
 Male 19 5 14
 Female 23 12 11
AJCC staging     6.959 0.008
 I-IIa 17 11 6
 IIb-IV 25 6 19
Histological grade     1.037 0.595
 Poor 14 7 7
 Moderate 15 6 9
 High 13 4 9
Classification     1.993 0.158
 Adenocarcinoma 36 13 23
 Others 6 4 2
Lymph node metastasis     8.968 0.003
 Positive 24 5 19
 Negative 18 12 6