Dysregulation of microRNA biogenesis in cancer: the impact of mutant p53 on Drosha complex activity

Table 1 MiRNAs regulated by mutant p53

miRNA	References	Biological functions	References
Transcriptionally regulated
27a	75	Cell growth, tumorigenesis	75
let7i	76	Inhibition of cell invasion and migration	76
130b	77	EMT repression	77
155	78	Cell invasion, metastasis	78
128-2	79	Anti-apoptotic, chemoresistance	79
223	80	Pro-apoptotic	80
520 g	57	Chemoresistance	81
518b	57	Inhibition of cell proliferation and invasion	82
582	57	Inhibition of cell proliferation and invasion	83
141	57	EMT repression	84
519c	57	Inhibition of angiogenesis	85
143	57	cell cycle arrest, apoptosis	86, 87
142	57	Inhibition of cell proliferation, migration, invasion	88
Post-transcriptionally regulated
26a	56	Repression of EMT and invasion	56
16	52	Inhibition of cell growth and angiogenesis	52
206	52	Inhibition of cell growth and angiogenesis	93
18a	58	Cell proliferation, invasion, tumorigenesis	58
517a	57	Inhibition of proliferation, apoptosis	57, 89
218	57	Inhibition of EMT and invasion	57, 90
519a	57	Inhibition of proliferation, migration and EMT	57, 91
105	57	Inhibition of proliferation	57
628	57	Unknown
515	57	Inhibition of proliferation, apoptosis	92
1	57	Suppression of cell growth, invasion, metastasis	93

The table lists miRNAs regulated by mutp53 both at transcriptional and post-transcriptional level. Biological functions of miRNAs and references are mentioned (on the left references relatives to the mut p53-dependent regulation, on the right those referred to their biological role)

ISSN: 1756-9966