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Table 1 MiRNAs regulated by mutant p53

From: Dysregulation of microRNA biogenesis in cancer: the impact of mutant p53 on Drosha complex activity

miRNA References Biological functions References
Transcriptionally regulated
 27a 75 Cell growth, tumorigenesis 75
 let7i 76 Inhibition of cell invasion and migration 76
130b 77 EMT repression 77
 155 78 Cell invasion, metastasis 78
128-2 79 Anti-apoptotic, chemoresistance 79
 223 80 Pro-apoptotic 80
520 g 57 Chemoresistance 81
518b 57 Inhibition of cell proliferation and invasion 82
 582 57 Inhibition of cell proliferation and invasion 83
 141 57 EMT repression 84
519c 57 Inhibition of angiogenesis 85
 143 57 cell cycle arrest, apoptosis 86, 87
 142 57 Inhibition of cell proliferation, migration, invasion 88
Post-transcriptionally regulated
 26a 56 Repression of EMT and invasion 56
 16 52 Inhibition of cell growth and angiogenesis 52
 206 52 Inhibition of cell growth and angiogenesis 93
 18a 58 Cell proliferation, invasion, tumorigenesis 58
517a 57 Inhibition of proliferation, apoptosis 57, 89
 218 57 Inhibition of EMT and invasion 57, 90
519a 57 Inhibition of proliferation, migration and EMT 57, 91
 105 57 Inhibition of proliferation 57
 628 57 Unknown  
 515 57 Inhibition of proliferation, apoptosis 92
 1 57 Suppression of cell growth, invasion, metastasis 93
  1. The table lists miRNAs regulated by mutp53 both at transcriptional and post-transcriptional level. Biological functions of miRNAs and references are mentioned (on the left references relatives to the mut p53-dependent regulation, on the right those referred to their biological role)