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Table 1 Metabolic analysis (AK4 shRNA vs control shRNA)

From: Modulation of anti-cancer drug sensitivity through the regulation of mitochondrial activity by adenylate kinase 4

Metabolite KEGG ID Ratio P-value
N-Acetylglucosamine 6-phosphate C00357 1.95 0.006
NADP+ C00006 1.8 0.003
XA0013 No ID 1.72 0.038
UDP-glucuronic acid C00167 1.6 0.001
Inosine C00294 1.6 0.185
CoA_divalent C00010 1.55 0.005
N-Acetylcysteine C06809 1.53 0.012
Fructose 1,6-bisphosphate C00354 1.53 0.003
Cysteine C00097, C00736, C00793 1.52 0.004
Butyrylcarnitine C02862 1.51 0.011
N-Acetylglucosamine 1-phosphate C04256 1.49 0.002
1-Methyl-4-imidazoleacetic acid C05828 1.46 0.038
UDP-N-acetylglucosamine C00043 1.44 0.001
Rhein C10401 1.43 0.044
4-Guanidinobutyric acid C01035 1.41 0.005
1H-Imidazole-4-propionic acid No ID 1.41 0.031
Alanine C00041, C00133, C01401 1.38 0.001
XC0016 No ID 1.38 0.001
ADP-glucose GDP-fucose C00498, C00325 1.34 0.013
Creatine C00300 1.31 0.011
UDP-glucose UDP-galactose C00029, C00052 1.31 0.001
dTDP-glucose C00842 1.3 0.014
Adenosine 5΄-phosphosulfate C00224 1.29 0.041
Argininosuccinic acid C03406 1.26 0.008
Myo-inositol 2-phosphate No ID 1.26 0.006
Glucose 1-phosphate C00103 1.25 0.025
Pantothenic acid C00864 1.24 0.022
Isethionic acid C05123 1.23 0.129
Malic acid C00149, C00497, C00711 1.23 0.02
CMP-N-acetylneuraminate C00128 1.23 0.013
Hippuric acid C01586 1.22 0.098
XA0033 No ID 1.22 0.022
Phosphocreatine C02305 1.2 0.324
CTP C00063 1.2 0.021
N-Formylmethionine C03145 1.2 0.012
S-Adenosylmethionine C00019 1.2 0.015
GTP C00044 1.2 0.009
Cys-Gly C01419 1.2 0.34
2-Aminobutyric acid C02261, C02356 1.19 0.015
Hydroxyproline C01157 1.19 0.021
ATP C00002 1.19 0.001
Threonic acid C01620 1.18 0.03
N-Acetylaspartic acid C01042 1.17 0.007
Asparate C00049, C00402, C16433 1.16 0.009
Fumaric acid C00122 1.16 0.027
N-Acetylalanine No ID 1.16 0.049
UTP C00075 1.14 0.007
Threonine C00188, C00820 1.11 0.002
Homocitrulline C02427 1.07 0.041
Betaine C00719 0.91 0.034
Glutamine C00025, C00217, C00302 0.89 0.009
1-Methylnicotinamide C02918 0.89 0.049
Proline C00148, C00763, C16435 0.89 0.041
Arginine C00062, C00792 0.86 0.042
UDP C00015 0.86 0.021
dTMP C00364 0.85 0.024
NMN C00455 0.84 0.008
Taurine C00245 0.82 0.011
5-Aminovaleric acid C00431 0.81 0.001
Isovalerylcarnitine No ID 0.79 0.013
Gluconic acid C00257 0.79 0.008
N-Acetylglutamic acid C00624 0.78 0.006
AMP C00020 0.73 0.007
Ala-Ala C00993 0.71 0.36
GABA C00334 0.71 0.001
Glutathione (GSSG)_divalent C00127 0.71 0.024
dTDP C00363 0.7 0.004
XA0012 No ID 0.7 0.001
XA0027 No ID 0.7 0.02
N-Acetylputrescine C02714 0.7 0.002
Adenosine C00212 0.68 0.005
Gluconolactone C00198 0.66 0.036
dADP C00206 0.65 0.027
XC0132 No ID 0.59 0.002
GMP C00144 0.58 0.002
γ Glu-Cys C00669 0.55 0.006
2΄-Deoxyadenosine
5΄-deoxyadenosine
C00559, C05198 0.53 0.024
Acetylcholine C01996 0.5 0.007
3-Phosphoglyceric acid C00197 0.44 0.002
Phosphoenolpyruvic acid C00074 0.42 0.025
NADPH C00005 0.36 0.044