Table 1 Metabolic analysis (AK4 shRNA vs control shRNA)
Metabolite | KEGG ID | Ratio | P-value |
|---|---|---|---|
N-Acetylglucosamine 6-phosphate | C00357 | 1.95 | 0.006 |
NADP+ | C00006 | 1.8 | 0.003 |
XA0013 | No ID | 1.72 | 0.038 |
UDP-glucuronic acid | C00167 | 1.6 | 0.001 |
Inosine | C00294 | 1.6 | 0.185 |
CoA_divalent | C00010 | 1.55 | 0.005 |
N-Acetylcysteine | C06809 | 1.53 | 0.012 |
Fructose 1,6-bisphosphate | C00354 | 1.53 | 0.003 |
Cysteine | C00097, C00736, C00793 | 1.52 | 0.004 |
Butyrylcarnitine | C02862 | 1.51 | 0.011 |
N-Acetylglucosamine 1-phosphate | C04256 | 1.49 | 0.002 |
1-Methyl-4-imidazoleacetic acid | C05828 | 1.46 | 0.038 |
UDP-N-acetylglucosamine | C00043 | 1.44 | 0.001 |
Rhein | C10401 | 1.43 | 0.044 |
4-Guanidinobutyric acid | C01035 | 1.41 | 0.005 |
1H-Imidazole-4-propionic acid | No ID | 1.41 | 0.031 |
Alanine | C00041, C00133, C01401 | 1.38 | 0.001 |
XC0016 | No ID | 1.38 | 0.001 |
ADP-glucose GDP-fucose | C00498, C00325 | 1.34 | 0.013 |
Creatine | C00300 | 1.31 | 0.011 |
UDP-glucose UDP-galactose | C00029, C00052 | 1.31 | 0.001 |
dTDP-glucose | C00842 | 1.3 | 0.014 |
Adenosine 5΄-phosphosulfate | C00224 | 1.29 | 0.041 |
Argininosuccinic acid | C03406 | 1.26 | 0.008 |
Myo-inositol 2-phosphate | No ID | 1.26 | 0.006 |
Glucose 1-phosphate | C00103 | 1.25 | 0.025 |
Pantothenic acid | C00864 | 1.24 | 0.022 |
Isethionic acid | C05123 | 1.23 | 0.129 |
Malic acid | C00149, C00497, C00711 | 1.23 | 0.02 |
CMP-N-acetylneuraminate | C00128 | 1.23 | 0.013 |
Hippuric acid | C01586 | 1.22 | 0.098 |
XA0033 | No ID | 1.22 | 0.022 |
Phosphocreatine | C02305 | 1.2 | 0.324 |
CTP | C00063 | 1.2 | 0.021 |
N-Formylmethionine | C03145 | 1.2 | 0.012 |
S-Adenosylmethionine | C00019 | 1.2 | 0.015 |
GTP | C00044 | 1.2 | 0.009 |
Cys-Gly | C01419 | 1.2 | 0.34 |
2-Aminobutyric acid | C02261, C02356 | 1.19 | 0.015 |
Hydroxyproline | C01157 | 1.19 | 0.021 |
ATP | C00002 | 1.19 | 0.001 |
Threonic acid | C01620 | 1.18 | 0.03 |
N-Acetylaspartic acid | C01042 | 1.17 | 0.007 |
Asparate | C00049, C00402, C16433 | 1.16 | 0.009 |
Fumaric acid | C00122 | 1.16 | 0.027 |
N-Acetylalanine | No ID | 1.16 | 0.049 |
UTP | C00075 | 1.14 | 0.007 |
Threonine | C00188, C00820 | 1.11 | 0.002 |
Homocitrulline | C02427 | 1.07 | 0.041 |
Betaine | C00719 | 0.91 | 0.034 |
Glutamine | C00025, C00217, C00302 | 0.89 | 0.009 |
1-Methylnicotinamide | C02918 | 0.89 | 0.049 |
Proline | C00148, C00763, C16435 | 0.89 | 0.041 |
Arginine | C00062, C00792 | 0.86 | 0.042 |
UDP | C00015 | 0.86 | 0.021 |
dTMP | C00364 | 0.85 | 0.024 |
NMN | C00455 | 0.84 | 0.008 |
Taurine | C00245 | 0.82 | 0.011 |
5-Aminovaleric acid | C00431 | 0.81 | 0.001 |
Isovalerylcarnitine | No ID | 0.79 | 0.013 |
Gluconic acid | C00257 | 0.79 | 0.008 |
N-Acetylglutamic acid | C00624 | 0.78 | 0.006 |
AMP | C00020 | 0.73 | 0.007 |
Ala-Ala | C00993 | 0.71 | 0.36 |
GABA | C00334 | 0.71 | 0.001 |
Glutathione (GSSG)_divalent | C00127 | 0.71 | 0.024 |
dTDP | C00363 | 0.7 | 0.004 |
XA0012 | No ID | 0.7 | 0.001 |
XA0027 | No ID | 0.7 | 0.02 |
N-Acetylputrescine | C02714 | 0.7 | 0.002 |
Adenosine | C00212 | 0.68 | 0.005 |
Gluconolactone | C00198 | 0.66 | 0.036 |
dADP | C00206 | 0.65 | 0.027 |
XC0132 | No ID | 0.59 | 0.002 |
GMP | C00144 | 0.58 | 0.002 |
γ Glu-Cys | C00669 | 0.55 | 0.006 |
2΄-Deoxyadenosine 5΄-deoxyadenosine | C00559, C05198 | 0.53 | 0.024 |
Acetylcholine | C01996 | 0.5 | 0.007 |
3-Phosphoglyceric acid | C00197 | 0.44 | 0.002 |
Phosphoenolpyruvic acid | C00074 | 0.42 | 0.025 |
NADPH | C00005 | 0.36 | 0.044 |